Abstract
The inhibitory action of four progestagens on oxidative drug metabolism was studied. p-Nitroanisole demethylation and aniline hydroxylation in phenobarbital stimulated rat liver musomes were inhibited by norethisterone acetate, d-norgestrel, lynestrenol and allylestrenol. Inhibitor constants were between 19 μM and 49 μM for p-nitroanisole demethylation and between 45 μM and 112 μM for aniline hydroxylation. The four steroids tested exhibited type I difference spectra in musomes under aerobic conditions. The spectral dissociation constants were in the same order of magnitude as the inhibitor constants.
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