Abstract
Aim:The present study aimed to examine the effects of sweet almond (Prunus amygdalus) suspension (SAS) on the measurements of blood biochemical parameters in male albino mice, in which hyperlipidemia was induced experimentally.Materials and Methods:Seventy male albino mice were divided randomly into seven groups (10 mice/group). The first group was the untreated control group (negative control). The second group comprised hyperlipidemic mice that did not receive SAS treatment (positive control). The other five groups consisted of hyperlipidemic mice that were orally administered five different doses of SAS (285, 571, 857, 1128, and 1428 mg/kg body weight). Hyperlipidemia was induced in mice by adding 1% cholesterol to the diet along with 0.5% H2O2 to the drinking water, with ad libitum access to both food and water for 60 consecutive days. Prothrombin time, partial thromboplastin time, clotting time, and platelet count were measured. Serum lipid profile (total cholesterol [TC], triacylglycerol [TAG], low-density lipoprotein cholesterol [LDL-C], very LDL-C [VLDL-C], and high-density lipoprotein cholesterol [HDL-C]) was also determined.Results:Prothrombin time, partial thromboplastin time, and clotting time significantly increased only in groups treated with SAS, especially at the dosage of 1428 mg/kg compared with the positive control group. Blood platelet count significantly decreased in SAS-treated groups. The serum levels of TC, TAG, LDL-C, and VLDL-C in the SAS-treated groups (857, 1128, and 1428 mg/kg) significantly decreased, whereas the serum level of HDL-C significantly increased compared with that of the positive control group.Conclusion:SAS administered orally at 1428 mg/kg body weight was the dose that most significantly decreased platelet count and serum levels of TC, TAG, LDL-C, and VLDL-C and increased prothrombin time, partial thromboplastin time, and clotting time as well as serum level of HDL-C in experimentally induced hyperlipidemic mice.
Highlights
Intake of excessive saturated fats and cholesterol leads to obesity, hyperlipidemia, and cardiovascular diseases such as myocardial infarction and arteriosclerosis, which causes cellular lipid peroxidation, enhances the occurrence of cancers and aging, and promotes biomembrane changes or destruction [1,2,3]
Prothrombin time, partial thromboplastin time, and clotting time significantly increased only in groups treated with sweet almond (Prunus amygdalus) suspension (SAS), especially at the dosage of 1428 mg/kg compared with the positive control group
In the previous studies conducted at our laboratory, we have reported the efficacy of aqueous and hexane extracts of sweet almond for treating hyperlipidemia in mice [7,8]
Summary
Intake of excessive saturated fats and cholesterol leads to obesity, hyperlipidemia, and cardiovascular diseases such as myocardial infarction and arteriosclerosis, which causes cellular lipid peroxidation, enhances the occurrence of cancers and aging, and promotes biomembrane changes or destruction [1,2,3]. Herbal medicines or phytomedicines have been reported to modulate various disease conditions such as cancer [4,5], diabetes [6], and hyperlipidemia [7,8], affect the reproductive system in male rodents [9,10] and promote wound healing [11]. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
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