Abstract
AbstractCells of an established cell line of poikilothermic origin (Gekko gecko) were transformed with SV40 virus and maintained at three temperatures: 23°, 30°, and 35°C. Cytogenetic analysis was undertaken at various times following infection. Increased chromosome damage, related to both incubation temperature and the length of time in culture, was observed in the virus‐transformed cells. A new “tetraploid” stem line arose in those cells cultured at 30°C; the presence of pairs of identical marker chromosomes suggests that this new stem line was derived through endoreduplication rather than the fusion of two cells.
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