Abstract
To investigate the effects of surfactant proteins B (SP-B) and C (SP-C) on lung mechanics, we compared tidal and static lung volumes of immature rabbits anesthetized with pentobarbital sodium and given reconstituted test surfactants (RTS). With a series of RTS having various SP-B concentrations (0-0.7%) but a fixed SP-C concentration (1.4%), both the tidal volume with 25-cmH2O insufflation pressure and the static volume deflated to 5-cmH2O airway pressure increased, significantly correlating with the SP-B concentration: the former increased from 6.5 to 26.0 ml/kg (mean), and the latter increased from 6.4 to 31.8 ml/kg. With another series of RTS having a fixed SP-B concentration (0.7%) but various SP-C concentrations (0-1.4%), the tidal volume increased from 5.1 to 24.8 ml/kg, significantly correlating with the SP-C concentration, whereas the static volume increased from 3.4 to 32.0 ml/kg, the ceiling value, in the presence of a minimal concentration of SP-C (0. 18%). In conclusion, certain doses of SP-B and SP-C were indispensable for optimizing dynamic lung mechanics; the static mechanics, however, required significantly less SP-C.
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Schedule a callMore From: Journal of applied physiology (Bethesda, Md. : 1985)
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