Abstract
Growing rabbits were given a fluoride supplement of 0.5 and 10 mg of fluoride per kg body weight per day during 14 weeks, that is, until they were 21 weeks of age. At that time the fluoride supplement was withdrawn and the animals were followed for another 24 weeks. Cortical diaphyseal bone from femur and tibia was studied by microradiography and fluorescence microscopy after fluorochrome labelling. There were no differences in bone morphology between the group given 0.5 mg of fluoride and the control animals. In animals given 10 mg of fluoride, excessive periosteal bone formation was seen at the lateral part of the tibial cortex. This fluorotic bone was characterized by thin radiating and heavily labelled bone trabeculae and there was a considerable degree of porosity in this bone. After withdrawal of the fluoride, no further signs of trabecular bone formation were seen. With increasing time of observation the porosity gradually decreased. The findings support the view that change from a high fluoride intake to a normal diet will result in progressive normalization of bone morphology. This normalization will occur in spite of maintained fluoride contents in the bone ash.
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Schedule a callMore From: Acta Pathologica Microbiologica Scandinavica Section A Pathology
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