Effects of supplementation with lactic acid bacteria isolated from Gajami sik‐hae on lipid and carnitine profiles in C57BL/6J mice fed high‐fat diet

Abstract

This study investigated the effect of lactic acid bacteria isolated from Gajami sik‐hae (Korea traditional salt fermented flat‐fish, GL42) on obesity in C57BL/6J mice fed a high fat diet. Male C57BL/6J mice, aged 4 weeks, were divided in to four groups according to supplement concentration; NDC (normal diet & DW), HDC (high fat diet & DW), HD‐GL42H (high fat diet & 1×109 CFU per mouse), HD‐GL42L (high fat diet & 1×107CFU per mouse). After 12 weeks, GL42 reduced body weight without reducing energy intake, and caused a significant, specific reduction in epididymal and back fat. Concentrations of triglyceride and total cholesterol were significantly lowered in GL42 goups, whereas that of adiponectin was increased. Hepatic carnitine palmitoyltransferase and peroxisome proliferator‐activated receptor‐α were highest, but peroxisome proliferator‐activated receptor‐γ as lowest in the GL42 groups. These results suggest that supplementing with lactic acid bacteria isolated from Gajami sik‐hae might have an antiobesity effect on high fat induced obese mice. (This work was supported by grant No. 10027215 from Ministry of Commerce, Industry and Energy)