Effects of supplementation of conjugated linoleic acid with gamma‐oryzanol on body fat mass in healthy overweight Korean women

Abstract

This study was done to investigate the enhancement effects of human body fat reduction of CLA with the supplementation of γ‐oryzanol(OZ) on overweight Korean women(n=51, BMI>23). The subjects were divided into 4 groups of control (olive oil), CLA, glyceride form of CLA(GCLA), CLA plus OZ(CLA‐OZ) in randomized, double‐blinded placebo‐controlled study. The soft‐gel capsule(500mg) was used to deliver control(500mg olive oil), CLA(500mg CLA), GCLA(500mg GCLA), and CLA‐OZ(500mg CLA+ 50mg OZ). Three capsules were taken twice a day for 12 weeks. There were no significant differences among 4 groups in energy intake and energy expenditure for the test periods. The CLA‐OZ treatment reduced 1.14kg body fat mass(BFM), whereas CLA, GCLA treatment reduced only 0.36 and 0.71 kg BFM determined by DEXA. Control treatment rather elevated 0.02 kg BFM. As considered subject variations, CLA‐OZ reduced body fat ranged from 7.9% to ‐2.7%, equivalent to 5.6 kg loss to 0.7 kg gain in body fat mass, against CLA. Therefore CLA‐OZ treatment seemed to most effectively reduce body fat, relative to CLA, GCLA and control treatment groups although the reduction by CLA‐OZ were not significantly different from CLA or GCLA group. Also no difference was seen in LBM from all treatments. All biochemical markers analyzed for safety were not significant different within or between groups and were within the normal range. The CLA‐OZ supplement significantly reduced blood pressure, as compared to the supplementation of CLA, GCLA and control. These results that OZ could be a useful ingredient to mix with CLA for the reduction of human body fat. However further studies are needed to confirm the enhancement effect of CLA‐OZ with more subjects and longer treatment periods.