Abstract
Infectious Bovine Rhinotracheitis (IBR), caused by bovine herpesvirus-1, contributes significantly to economic losses in the dairy and beef cattle industry. Lysin e has been shown reduce virulence of herpesviruses in felids and humans. Our objective was to evaluate the effects o f supplemental lysine on serum IBR antibody titer a nd rectal temperature in response to a modified-live Intranas al (IN) or Intramuscular (IM) respiratory-virus vac cination. Sixty-four neonatal Holstein bull calves (7±2 d of age; BW = 37±4.2 kg) were used in a completely randomized design. Calves were fed milk replacer supplemented with either 17 g/d L-lysine monohydrochloride (LYS; 28 calves) or an equivalent amount of casein (CAS; 28 calves) for 42 d. Calves were then vaccinated with either an IN IBR-Parainfluenza virus-3 (PI3) or an IM (IBR-PI3-bovine viral diarrhea type I and II, bovine respi ratory syncytial virus) modified-live vaccine on d 36. A c ontrol group (8 calves) received no supplement or v accination. All calves were housed in individual calf pens (1.2 ◊2.1 m). Daily feed intakes were monitored and BW measured weekly. Calves were bled on d 0, 35, 36, 37 and 42. Temperature data loggers were attached to rectal p robes and temperatures were recorded every 5 min from d 28 to d 42. No significant differences were determined f or average performance, rectal temperature, or IBR antibody titers with either IN or IM vaccinations betw een LYS and CAS treated calves (p>0.10). However, serum urea nitrogen and the ratio of serum lysine: Arginine increased (p<0.05) for LYS compared to CAS calves. These results suggest that supplementing lysine impacts nitro gen metabolism but does not alter the response to IBR v accination or animal performance in neonatal Holstein calves.
Highlights
Fora secondary bacterial infection (Yates, 1982)
Serum urea nitrogen and the ratio of serum lysine: Arginine increased (p
These results suggest that supplementing lysine impacts nitrogen metabolism but does not alter the response to Infectious Bovine Rhinotracheitis (IBR) vaccination or animal performance in neonatal Holstein calves
Summary
Fora secondary bacterial infection (Yates, 1982). Herpes viruses are difficult to eradicate due to the establishment of. The susceptibility of the respiratory tract to bacterial latency after exposure (Nandi et al, 2009). Such as those experienced during shipping and processing, Bovine Herpesvirus-1 (BHV-1) is one of the foremost can stimulate the virus to emerge from latency, inducing infections contributing to Bovine Respiratory Disease diseaseand further spreading the virus (Perez et al, 2005). An infection of BHV-1 can Bovine herpesvirus-1 is very common; cattle herds of over lead to Infectious Bovine Rhinotracheitis (IBR), 400 head may have BHV-1 prevalence of over 85%. BHV-1 that attempt to provide enough immunity to avoid reactivation of the disease. Humoral immunity is not always sufficient and reactivated-induced disease puts cattle at risk for developing BRD (Jones and Chowdhury, 2007)
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