Abstract
In this work, the effects of four supercritical carbon dioxide (ScCO2) conditions potentially conductive to sterilization, on physicochemical characteristics of a liposome formulation containing apigenin (AG) were investigated. These conditions were: C1 (ScCO2/70 °C/150 bar/240 min), C2 (ScCO2/0.25% water/ 0.15% H2O2)/ 0.5% acetic anhydride/38 °C/85 bar/45 min), C3 (ScCO2/0.08% peracetic acid/35 °C/104 bar/180 min) and C4 (ScCO2/ 200 ppm H2O2/40 °C/270 bar/90 min). The results showed changes in color and a decrease in pH value of liposomes suspension after treatment with all tested conditions. Moreover, a decrease in liposome size with C1, C2 and C3 and an increase in the PDI with C1 and C3 were observed. For zeta potential, a decrease with C1, and an increase with C2 and C3 were found. Concerning the encapsulated AG, a moderate decrease, a strong decrease and a total disappearance were noted with conditions C1, C2 and C3 respectively.
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