Abstract
Rats were fed a diet based on unheated soybean flour without vitamin B<sub>12</sub> added. This diet leads to a depletion of vitamin B<sub>12</sub> as evinced from a decrease in liver concentration of the vitamin and an increased urinary excretion of methylmalonic acid following a load of propionate. Urinary excretion of formiminoglutamic acid after a histidine load was likewise increased. Supplementation of this diet with either methionine or cysteine improved weight gain, increased liver level of vitamin B<sub>12</sub> and decreased excretion of methylmalonic and formiminoglutamic acids. Choline raised liver vitamin B<sub>12</sub> and decreased excretion of methylmalonic acid. Addition of both choline and methionine to the diet increased liver vitamin B<sub>12</sub> more than choline or methionine alone and decreased excretion of formiminoglutamic acid more than choline alone.
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