Abstract
The intestinal transport of the 3-α-sulfate esters of glycolithocholic and taurolithocholic acids was studied in an animal model (guinea pig). Absorption of these compounds was by active transport and was limited to the ileum. This contrasts with the nonsulfated compounds which can be reabsorbed from all sections of the small bowel. Absorption of the nonsulfated compounds was greater in the distal region, probably reflecting two processes: (1) active absorption and (2) passive diffusion. In the proximal regions, only passive diffusion occurred. Ileal transport of sulfated taurolithocholate was depressed by the presence of sodium taurocholate. These results support the concept that sulfation of the potentially toxic lithocholic acid bile salts could curtail their intestinal absorption and enhance their fecal elimination rates.
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