Effects of sufentanil on cardiovascular responses in elderly patients during intubation after anesthetic induction under bispectral index monitoring

Abstract

Objective To provide reasonable usage of medications by observing the effects of different doses of sufentanil on the circulatory system in elderly patients during induction of general aneasthesia under real-time monitoring of BIS.Methods 60 ASA Ⅰ and Ⅱ elderly patients undergoing elective abdominal surgeries were selected and randomly divided into three groups ( 20 for each group ):groups with sufentanil of 0.2 μg/kg ( group S1 ),0.3 μg/kg ( group S2 ),and 0.4 μg/kg ( group S3 ).The BIS values were ( 50 ± 5 ) during intubation and TCI of propofol was maintained.SBP,DBP,BIS values,HR,and dosage of propofol were recorded before aneasthesia ( T0 ) and intubation ( T1 ),and at the moment of completion of intubation ( T2 ),2 min ( T3 ),and 5 min after intubation ( T4 ).Results Before intubation,BIS values maintained at( 50 ± 5 )in all the three groups,with no significant differences.Blood pressure decreased at T1 as compared with TO in all the three groups,and did not differ significantly among the three groups.After intubation,the level of hemodynamic fluctuation was markedly higher in group S1 than in group S2 and group S3.The change in hemodynamics was least in group S3.Conclusions Intravenous sufentanil of 0.4 μg/kg can effectively inhibit cardiovascular stress responses in elderly patients and can keep the circulatory system stable. Key words: Sufentanil; Elderly; Tracheal intubation; Bispectral index; Cardiovascular responses