Abstract
During vascular perfusion of the cochlea with substrate free synthetic blood, the endolymphatic potential (EP) is maintained for 85 ± 20 (SD) minutes. The subsequent decline of the EP can be prevented by 0.8 mM glucose or by 11 mM lactate, but not by succinate (although 20 mM succinate effects a partial recovery of the EP when it has declined by 40 mV). Significant breakdown of strial glycogen occurs only when the EP starts to decline. Glycogen stores in the stria are virtually depleted when the EP has dropped to about 30 mV. At about the same time, the further decline of the EP is arrested, presumably due to activation of a new substrate pool. Only following a stabilization of some 30 min does the EP resume its decline. It appears that the prolonged initial maintenance of the EP during substrate free vascular perfusion is due to the utilization of glucose from cochlear fluids, since the EP starts to decline immediately when the perilymphatic glucose pool is removed simultaneously by perilymphatic perfusion. [Supported by NIH and NSF.]
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