Abstract
Nutritional status influences the activity of drug metabolizing enzymes in the liver (Alvares et al. 1980; Basu and Dickerson 1974; Campbell and Hayes 1976; Mag-dalou et al. 1979). Deficiency of protein decreases the activity of the mixed-function oxidase system (cf. Hathcock 1985). Since glutathione (GS) and GS-related enzymes play an important role in the detoxification processes, the influence of subchronic low-protein diet (LPD) on GS content and GS-related enzyme activities was investigated in the liver, kidney, and gonads in the rat in order to develop an experimental system which may be used as a model to study the effect of drugs in protein-deficient animals.
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