Effects of structured fat emulsion and medium / long chain fat emulsion on patients after hepatectomy

Abstract

Objective To analyze the effects of structured fat emulsion and medium/long chain fat emulsion on blood lipids, immune cells and acute inflammation after hepatectomy for hepatocellular carcinoma. Methods Total of 60 patients with hepatocellular carcinoma who underwent hepatectomy in Henan People's Hospital (Zhengzhou University People's Hospital) from January 2013 to March 2017 were divided into experimental group (using structured fat emulsion) and control group (using medium/long chain fat emulsion), 30 cases in each group. Triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), T lymphocyte level, fibrinogen (FIB), C-reactive protein (CRP), prostaglandin E2 (PGE2) were detected before and 2, 4, 6 and 8 days after infusion. Results There were no significant differences in LDL-C, HDL-C, TG and TC between the two groups before infusion (P>0.05). On the 2nd day of parenteral nutrition infusion, the level of blood lipids in both groups was higher than experimental group before infusion; on the 4th, 6th and 8th day of infusion, LDL-C, HDL-C, TG and TC in the control group were higher than those in the experimental group (P<0.05). After parenteral nutrition infusion, the levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in both groups were higher than experimental group before infusion, and the experimental group was higher than the control group, the differences were statistically significant (P<0.05). Compared with before infusion, level of FIB, CRP and PGE2 began to increase on the 2nd day of infusion, and the differences were statistically significant (P<0.05). On the 2nd, 4th, 6th and 8th day, CRP in the control group was higher than experimental group. And resepeatively (19.12±5.84) mg/ml vs. (13.76±2.36) mg/ml, (31.67±8.68) mg/ml vs. (17.21±2.66) mg/ml, (22.15±8.33) mg/ml vs. (12.48±0.63) mg/ml, (9.65±4.66) mg/ml vs. (7.52±0.99) mg/ml, and PGE2 were also higher than that in the experimental group (P<0.05). Conclusion Structured fat emulsion is superior to medium/long chain fat emulsion in improving blood lipid, immune cells and inflammatory reaction in patients after hepatectomy. Key words: Carcinoma, hepatocellular; Fat emulsions, intravenous; Lipid metabolism