Effects of stress response induced by laparoscopic colectomy and laparotomy on TLR-mediated innate immune responses in colon cancer patients

Abstract

Abstract Objectives Colon cancer patients were analyzed to compare the effects of surgical trauma on immune function by detecting the activation degree of cell inflammatory cytokines levels after different surgical procedures. Methods In total, 107 patients with colon cancer were divided into open surgery group and laparoscopic surgery group. Serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14) and myeloid differentiation protein-2 (MD-2) levels were detected before, after and one day after surgery. Results Serum CRP, IL-6 and TNF-α levels in both groups were significantly increased at all postoperative time points after surgery compared with those preoperatively. CRP, IL-6 and TNF-α levels in the laparoscopic group were lower than that in the open surgery group at all time points after surgery. Serum IL-6 and TNF-α levels in open surgery group were significantly lower than those in the laparoscopic surgery group after LPS stimulation. Laparoscopic surgery led to the decrease of serum CD14, TLR4 and MD-2 levels. The incidence of postoperative complications in laparoscopic group was significantly less as compared to the open surgery group. Conclusions Cellular immunity may be better presented after laparoscopic surgery in comparison with open surgery. Laparoscopic complete mesenteric resection surgery is effective in the treatment of colon cancer.