Abstract
Glucorticosteroids, and estradiol increase the cyclic AMP response of lymphocytes to isoproterenol and PGE. This response, unlike the usual steroid responses initiated by specific cytoplasmic steroid receptors, does not require the biosynthesis of macromolecules for its activity. The effect may depend partially on the inhibitory effect of steroids on cyclic nucleotide phosphodiesterase. The potentiating effect of steroids however, is greater than that can be achieved with theophylline, a more potent inhibitor of phosphodiesterase prepared from lymphocytes.
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