Abstract
RELATIONSHIPS, both general and specific, between ovarian function and seizure susceptibility have long been postulated. Analysis of patients who have the onset of a seizure disorder in the age range 10 to 20 years indicates a prevalence of females among patients subject to petit mal 1 and to seizures of other forms. 2 Significant age-related sex differences occur in the incidence of light-evoked electroencephalographic abnormalities with a higher incidence in the female during the years of active ovarian function. 3 Seizures in many females are increased in their frequency in relation to the menstrual cycle. Logothetis et al 4 postulated that a premenstrual exacerbation of seizures might be related to increased estrogenic activity. A lowering of electroshock threshold during estrus in the rat has been related to high levels of circulating estradiol during this phase. 5 The exact relation of circulating estrogenic substances to seizure exacerbations in the human
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