Abstract
BackgroundLong-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in CKD + CAD patients.MethodsWe compared the effects of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD.ResultsLong-term statin therapy was much more effective in the CKD + CAD patients compared with CKD patients. In the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P = 0.012). With regard to the all-cause and cardiac deaths, long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001). In contrast, long-term statin therapy exerted no significant influence on the clinical outcomes of the CKD-only patients.ConclusionLong-term statin therapy more dramatically reduced the CVs and mortality rates of the CKD patients with concomitant CAD. In contrast, CKD-only patients had a good prognosis and did not appear to require statin treatment.
Highlights
Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of cardiovascular diseases (CVD), and renoprotective effect on Chronic kidney disease (CKD) patients
128 CKD patients were considered to have concomitant coronary artery disease (CAD) if they were diagnosed with CAD by coronary angiogram (CAG), patients received a stent graft or coronary artery bypass grafting surgery according to the extent of their lesions, and 126 CKDonly patients were randomly selected for the control groups
It is noteworthy that Hypertension, myocardial infarction, smoking, and angina pectoris were more common in the CKD + CAD group
Summary
Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients [15, 16]. Very few reports are available from China to address the effects of statin therapy in CKD + CAD patients.
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