Effects of spinal tractotomy on spatial sequence recognition in macaques

Abstract

Five Macaca speciosa monkeys were trained to discriminate between the order of two tactile stimulus presentations (proximal-distal vs. distal-proximal) to the lateral calf. Psychophysical thresholds for tactile sequence recognition were obtained by varying the distance between the spots stimulated. Stabilized preoperative thresholds for stimulation on the lateral calf averaged 10.4 mm, which is comparable to point localization thresholds for sequential contact of the proximal limbs of humans. Complete interruption of the ipsilateral fasciculus gracilis produced elevations of thresholds within the first 3 postoperative weeks to an average of 3.6 times the control values. With training over 6 postoperative months, normal discrimination recovered. In contrast to the effects of dorsal column (DC) lesions, interruption of the lateral and ventral columns ipsilaterally or contralaterally produced no deficit or a mild and transient deficit. Monkeys with isolation of either the ipsilateral dorsolateral column (ILC) or the contralateral ventral quadrant (CVQ) exhibited substantial and enduring deficits. Thresholds were elevated an average of 5 times the control values, and recovery was not observed or was incomplete after months of training. In contrast, isolation of the ipsilateral dorsal column produced little or no threshold elevation. The results of isolating lesions complement the series of primary lesions to each cord sector, showing that spatiotactile sequence recognition for the hindlimb is served more critically by the dorsal columns than by the lateral columns.