Abstract
Summary The trophic effects of spinal cord extract on resting potential, action potential and sensitivity of action potential to tetrodotoxin (TTX) in organ-cultured mouse skeletal muscle were examined. Spinal cord extract blocked decrease in the maximal rates of rise and fall of the action potential caused by cultivation and also partially prevented decrease in its TTX-sensitivity and in the resting potential. In another experiment, spinal cord extract was added to organ cultures of skeletal muscle that had been previously denervated for 3 days in vivo. Spinal cord extract partially reversed post-denervation fall in the maximal rate of rise of action potential and its TTX-sensitivity. Extracts of non-nervous tissues (kidney, spleen, pancreas and adrenal gland) were ineffective. These results indicate that mouse spinal cord appears to possess neurotrophic substance(s) regulating membrane properties of mouse skeletal muscle.
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