Abstract

Because of the development of spacecraft design and life-support technologies, people can be sent farther in space and kept there longer. The characteristics of the space environment include the space radiation, microgravity, temperature extremes, high vacuum, space debris and ionospheric plasma etc. Among them, the two major challenges associated with spaceflight are the biological effects of space radiation and microgravity. DNA, the genetic material, is a kind of important biologic molecule. The maintenance of the stability of genomic DNA affects many cellular events, which prevents diverse human diseases. DNA can accumulate numerous lesions which is the underlying hallmark of cancer, aging and many other diseases. It is well known that many environmental factors can affect the integrity of DNA molecules. Thus, it is important to investigate the effects of space environment on the maintenance of genomic stability. In this work, we investigated “Roles of space radiation on genomic DNA and its genetic effects” on board the SJ-10 recoverable microgravity experimental satellite (SJ-10 satellite), using the wild type and corresponding radiation sensitive mutant mammalian cells and fruit flies models created by our team.

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