Abstract
The effects of (a) 4, 5, 6 trinor-3, 7-inter-m-phenylene PGE 1 methyl ester, (b) 4, 5, 6 trinor-3, 7-inter-m-phenylene 3 oxa PGE 1 and (c) 4, 5, 6 trinor-3, 7-inter-m-phenylene 3 oxa PGE 1 methyl ester on human and guinea pig respiratory tract muscle in vitro and in vivo have been studied. All the analogues relaxed the isolated preparations of guinea-pig tracheal chain, human tracheal, bronchial and bronchiolar muscles and decreased histamine-induced lung resistance in the anaesthetised guinea pig. On some preparations the effects of the analogues were more pronounced than those of PGE 1. The results suggest that some of the inter-m-phenylene analogues of PGE 1 may be bronchodilators in asthmatics.
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