Abstract
The present study was conducted on the rat population of animal house in Madonna University, Elele Campus, Nigeria to evaluate the status of some biochemical parameters of rats administered with varied concentrations of chlorpheniramine maleate (piriton), cyproheptadine hydrochloride (cypron), and clemastine fumarate (tavagyl). Blood samples and liver organ were collected from 51 male and female albino rats, 48 were given different concentrations of each of the antihistamine drugs for 30 days, while 3 rats were used as control. Alanine amino transferase (ALT) activity and Aspartate amino transferase (AST) were lower in the control group compare to the groups administered with piriton, Cypron, and Tavagyl at 0.04mg/ml, 0.02mg/ml, 0.01mg/ml, and 0.005mg/ml. From the above results it is concluded that piriton, cypron, and Tavagyl increased the activities of AST and ALT enzymes.
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