Abstract
AbstractThe effects of the β‐carbolines, harmaline, harmalol, harmane, and harmine on 5‐hydroxytryptamine, dopamine, and tryptophan concentrations in the cerebral ganglion of the cockroach (Periplaneta americana) were investigated. Injection of harmaline and harmine‐induced decreases in the concentrations of 5‐hydroxytryptamine and dopamine. The 5‐hydroxytryptamine depletion was greater than the dopamine depletion. Injections of harmalol had no effect. Tryptophan concentrations were variable, although significant decreases were observed in harmaline‐treated animals. N‐acetyl 5‐hydroxytryptamine, 5‐hydroxyindoleacetic acid, and 5‐hydroxytryptophan remained below the level of detection in all tissues examined, indicating that these compound do not accumulate within the central nervous system as a result of the various treatments.
Published Version
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