Abstract
The effects of intravenous sodium selenite on several blood components were determined in dogs. Changes in plasma sodium, calcium, and phosphorus were inconstant. Although the terminal plasma protein levels were unaffected by low doses of selenite, 2.0 mg/kg Se produced an elevated plasma protein. Increases in hematocrit and plasma levels of potassium, lactate, and pyruvate were significant, as was the fall in venous pH. These findings may result from a combination of “epinephrine” release, decreased cardiac output and plasma flow, hemoconcentration, and enzyme inhibition.
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