Effects of sodium hyaluronate compared with steroid eye drop against the degree of canalicular stenosis in breast cancer patients treated with docetaxel

Abstract

Canalicular stenosis caused by inflammatory processes in the mucosa of canalicular causing thickening of the squamous epithelium, subsequently parakeratosis and hyperkeratosis of the squamous epithelium. The aim of this study was to assess the effects of sodium hyaluronate compared with steroid eye drop against the degree of canalicular stenosis in breast cancer patients treated with docetaxel chemotherapeutic agents. This study was a clinical trial with the randomized controlled trial (RCT) of 80 sample during the period August-October 2017. Bivariate analyzes used chi-square and McNemar test, and multivariate analysis used logistic regression with the backward method. A total of 20 samples with moderate degree stenosis became mild degree and 36 samples with mild degree stenosis became not stenosis after treated with sodium hyaluronate eye drops. A total of 16 samples with moderate degree stenosis became mild degree and 36 samples with mild degree stenosis became not stenosis after treated with steroid eye drops. McNemar test showed a significant difference in the degree of stenosis after treated with sodium hyaluronate (p=0.039) and steroid eye drops (p=0.000), but chi-square test showed no significant difference in the degree of stenosis between sodium hyaluronate and steroid (p=0.302). Multivariate analysis showed that age, duration of administration and dose of docetaxel effects in canalicular stenosis. Administration of sodium hyaluronate and steroid eye drops can improve the degree of canalicular stenosis.