Abstract
In a previous report1 we observed an increase in toxicity of bile salts∗ injected intraperitoneally into the white mouse when sodium citrate was added. In the present study the effects of varying dilutions of bile salts and sodium citrate on human blood cells in vitro have been observed.When bile salts are added to red blood cells of different individuals and allowed to stand at room temperature for 18 hours, hemolysis occurs through dilutions of 1:200 to 1:6400. The bloods of 100 undiagnosed individuals were examined in order to determine their susceptibility to bile salt hemolysis. The large variation in ability of bile salts to hemolyse different bloods is independent of changes due to age of cells, and independent of the temperature and humidity under which the cells are kept.When sodium citrate is added to bile salts, hemolysis of red cells takes place in higher dilutions of the bile salts than when the bile salts per se are employed and the dilution at which hemolysis takes place depends upon the co...
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