Abstract
Objective: To investigate the clinical effect of alendronate on osteoporosis and its effect on Cyt C, Apaf-1 and caspase-9. Methods: 100 cases of bone fracture patients diagnosed as osteoporosis in the hospital from January 2014 to December 2016. After fracture fixation, the patients were randomly divided into control group and observation group. The control group with 50 cases was given Calcium and observation group with 50 cases were treated with alendronate on the basis of the control group. The bone pain degree, bone mineral density and bone biochemical indexes of the two groups were recorded and compared. The cytochrome C (Cyt C) and Apoptotic Protease activating Factor-1 (Apaf -1) and caspase-9 levels of the two groups was compared. Results: After treatment, the bone mineral density of both groups significantly increased, and the score of bone pain significantly decreased (P 0.05). Conclusion: Sodium alendronate can effectively ease the bone pain in osteoporosis patients, improve bone density, improve bone metabolism, and reduce the levels of apoptosis-related factors Cyt C, Apaf-1 and caspase-9 in bone tissue of patients.
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