Abstract
BackgroundSleeve gastrectomy (SG) has emerged recently as a stand-alone bariatric procedure to treat morbid obesity and enhance glucose homeostasis. The aim of the study was to evaluate its effects in neonatally streptozotocin (STZ)-induced diabetic rats (n-STZ diabetic rats).Methodology and Principal FindingsTo induce diabetes, STZ (90 mg/kg) was administered intraperitoneally to 2-day-old male pups. When 12 weeks old, diabetic rats were randomized into sleeve operation group (SLG, n = 6) and sham operation group (SOG, n = 6). Body weights were monitored weekly, and daily consumption of water and food were followed for eight consecutive weeks postoperatively. Serum glucose levels were measured periodically at the 4th and 8th week after surgery. Insulin, ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) levels were assayed at the end of the study. Our data showed that SLG rats exhibited significantly lower body weight gain in addition to reduced food and water intakes postoperatively compared to their sham-operation counterparts. However, resolution of diabetes was not observed in our study. Correspondingly, there were no significant differences between SOG rats and SLG rats in glucose metabolism-associated hormones, including insulin, GIP and GLP-1. In contrast, ghrelin level significantly decreased (P<0.01) in SLG group (58.01±3.75 pg/ml) after SG surgery compared to SOG group (76.36±3.51 pg/ml).ConclusionsThese observations strongly suggest that SG is effective in controlling body weight. However, SG did not achieve resolution or improvement of diabetes in n-STZ diabetic rats.
Highlights
Sleeve gastrectomy (SG) is one of the restrictive surgical procedures applied for treating morbid obesity consisting of removing the gastric fundus and transforming the stomach into a narrow gastric tube [1]
Hyperglycemia re-emerges when the neonatal rats grow into adults, and the rats gradually develop major features described in type 2 diabetes patients after adulthood [10,11,12]
Our results showed that SG was effective in restraining body weight gain and reducing food consumption of n-STZ diabetic rats, with an 8-week follow-up evaluation showing an effect that lasted
Summary
Sleeve gastrectomy (SG) is one of the restrictive surgical procedures applied for treating morbid obesity consisting of removing the gastric fundus and transforming the stomach into a narrow gastric tube [1]. This surgical procedure was initially performed as the first stage for the biliopancreatic diversion/ duodenal switch (BPD/DS) procedure, aiming to reduce operation risks for super-obese or high-risk patients; it has been validated as a stand-alone bariatric surgery nowadays [2,3]. When injected into adult rats, STZ can cause type 1 diabetes with severely elevated blood glucose levels. The aim of the study was to evaluate its effects in neonatally streptozotocin (STZ)induced diabetic rats (n-STZ diabetic rats)
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