Abstract
SK&F 96365 (1-[3-(4-methoxyphenyl)propoxyl]-1-(4-methoxyphenyl)ethyl-1 H-imidazole HCl) (1–50 μM), an inhibitor of receptor-mediated Ca 2+ entry, reduced both acetylcholine (ACh)- and 56 mM K + (high K +)-induced 45Ca 2+ influxes and catecholamine secretion in bovine adrenal chromaffin cells. However, SK&F 96365 at lower concentrations (1–3 μM) inhibited only ACh-induced 45Ca 2+ influx and secretion but not their high K +-induction. In Na +-free medium, ACh-induced 45Ca 2+ influx and secretion were also considerably decreased by SK&F 96365 at low concentrations (1–3 μM). These results suggest that in the chromaffin cells, not only voltage-sensitive calcium channels but also ACh receptor-operated calcium channels at least in part contribute to the influx of Ca 2+ which triggers the catecholamine secretion from the cells when the cells are exposed by ACh.
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