Abstract
Effects of single doses of radiation were studied on lung metastases of tumours in men, dogs and mice. A correlation was found between growth rate and radiosensitivity as determined from volume reduction of the metastases. In all cases an accelerated growth was observed after reduction of the volume by the irradiation. In this period of accelerated growth in the mouse tumour, an increase in the proliferative fraction and a shortening of the inter-mitotic time of the proliferative cells were measured. Based on the assumption that in the period of accelerated growth also in human tumours there could be a greater radiosensitivity than before irradiation, in two patients the effect of subsequent doses given during the period of accelerated growth, was studied. The results suggest that the second and perhaps the third dose has a greater effect on the volume reduction than the first dose of radiation.
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