Abstract
Arginine monochloride (5 g) was administered as a 2-min “pulse” to 24 normal male subjects. The amino acid-induced insulin release was maximal 2 min after the end of the pulse, and uniphasic in nature. A small rise in scrum glucose levels was observed starting 2 to 8 min after the pulse. Thus, the insulin-releasing and hyperglycemic properties of the amino acid were temporally dissociated in vivo. Repeated pulses of l-arginine-HCl (up to a maximum of 4) were at least equipotent in inducing insulin release. That is, there was no exhaustion of the pool of insulin acutely released after arginine.
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