Abstract
Objective To study the effects of simvastatin on the expression of vascular cell adhesion molecule-1 (VCAM-1) in monocmtaline (MCT)- induced pulmonary hypertension rats, and investigate the therapeutic mechanism of simvastatin to pulmonary hypertension. Methods 30 SD rats were divided into 3 groups, normal control group ( Con group) , MCT -induced pulmonary hypertension group (MCT group) and simvastatin treatment group (SS group). The rats in control group and therapeutic group were injected to induced pulmonary hypertension with MCT. After 3 weeks, the mean pulmonary arterial pressure (mPAP) and right ventricular hypertrophy index (RVHI)were measured, and the expression of VCAM-1 mRNA and protein in lung tissues were detected by RT-PCR and immunohistochemistry, respectively. Results mPAP, RVHI and the expression of VCAM-1 in lung tissues in MCT group were higher than those in Con group and SS group. Moreover, mPAP, RVHI and the expression of VCAM-1 in lung tissues had no difference between SS group and Con group. Conclusion Simvastatin has therapeutic effect on pulmonary hypertension through down-regulating the expression of adhesion molecule VCAM-1. Key words: Simvastatin/PD ; Monocrotaline/AE; Hypertension; pulmonary/CI; Vascular cell adhesion molecule-1/DE/ME
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