Abstract
ObjectiveThe aim of the present study was to evaluate the influence of simvastatin on mechanical properties of muscle and bone in hypercholesterolemic rats submitted to physical exercise. MethodsTen male Wistar rats were submitted to a high-fat diet rich in cholesterol for 90 days. The animals were then divided into two groups: animals treated with physical exercise (EG) and animals treated with physical exercise and simvastatin (ESG). Protocols for physical exercise in water and simvastatin administration were performed for eight weeks. After this period, the animals were euthanized; the left tibia and right gastrocnemius muscle were dissected for mechanical analysis, and the right tibia for densitometry. The data were analyzed using Student's t-test, considering a level of significance of 5%. ResultsThe comparison of maximum load and stiffness revealed no significant differences between the groups for both the tibia (p=0.851 and p=0.259) and the gastrocnemius (p=0.911 and p=0.083). The tibia BMD also showed no significant difference between the groups (p=0.803). ConclusionSimvastatin had no negative effects on mechanical properties in tibia and gastrocnemius of hypercholesterolemic rats submitted to physical exercise.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
