Abstract
Research was performed on free-ranging Sprague-Dawley strain rats using in vivo intracranial dialysis techniques combined with radioenzymatic analysis of dopamine level. Dialysis infusion of the n. accumbens with artificial cerebrospinal fluid containing a mixture of amphetamine and glutamate (each at a concentration of 10−3 M) was found to intensify synaptic dopamine release into the dorsal striatum, while administering these substances separately to the n. accumbens induces inhibition of synaptic dopamine release in this striatal area. Findings indicate that the n. accumbens exerts an influence on function of the nigrostriatal dopaminergic system and that the pattern of this influence may be determined by interaction between dopamine- and glutamatergic inputs from this nucleus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
