Effects of simple overweight or obesity on IVF/ICSI outcomes of young women

Abstract

Objective To investigate the influence of simple obesity and overweight on outcomes of in vitro fertilization-embryo transfer/intracytoplasmic sperm injection (IVF/ICSI) in young women (≤35 year-old). Methods The clinical data of 1 272 cases (1 272 cycles) of young infertile women who received primary IVF/ICSI for non-polycystic ovary syndrome(PCOS) in Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from January 2011 to December 2016 were retrospectively analyzed. Patients were divided into three groups according to body mass index (BMI), the normal weight group (901 cycles, BMI 18.50-24.0 kg/m2), overweight group (260 cycles, BMI 24.0-28.0 kg/m2) and obesity group (111 cycles, BMI≥28.0 kg/m2), to assess the influence of overweight and obesity on controlled ovarian hyperstimulation (COH), excellent rate of pregnancy outcomes, including clinical pregnancy rate, miscarriage rate, pregnancy induced hypertension syndrome (PIH), gestational diabetes mellitus (GDM), macrosomia and small for gestational age (SGA) infants. Results The rates of PIH, GDM and macrosomia in overweight group and obesity group were higher than those in normal weight group (P 0.05). There was no significant difference in abortion rate, ectopic pregnancy rate, live birth rate, premature birth rate and SGA rate among the three groups (P all>0.05). Conclusions In overweight and obese young patients with non-PCOS, with the increase in dosage of Gn, pregnancy rate will decrease, but risk of pregnancy complications development, such as GDM and macrosomia, will increase. Key words: Overweight; Obesity; In vitro fertilization-embryo transfer; Assisted reproduction outcome