Abstract
The effects of a short-term treatment with lithium carbonate on lymphocytes and granulocytes were studied in six normal subjects. The lithium effects are related to a direct, immediate and quickly reversible action of the drug on the bone marrow, as demonstrated by the granulocyte number and variations in Arneth's index. Although lymphocyte and granulocyte functions do not seem to be affected by lithium when investigated by the usual methods, the ability of the drug to counteract the theophylline-induced inhibition of cellular functions would suggest that lithium acts mainly through the modulation of intracellular levels of cyclic nucleotides. This is confirmed by evaluation of cellular cyclic 3',5'-adenosine monophosphate (cAMP). The above hypothesis could explain the quick onset and loss of lithium action on granulopoiesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
