Abstract
To elucidate the effects of Sho-saiko-to extract and its components, baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, against the effects of longer periods of acute hepatic injury induced by CCl 4, we measured serum ALT activity in male Wistar rats for five days after ip administration of CCl 4 (0.2 ml/kg), and examined the daily changes of the pharmacokinetic behavior of salicylamide (SAM) for five days. Serum ALT activity rose to a maximum level within a day after administration of CCl 4 and then decreased to the control level after three. Sho-saiko-to extract and its components could suppress this acute change in serum ALT activity to less than 50% of CCl 4 alone. However, the pharmacokinetics of SAM showed that liver function recovers in a biphasic manner, so that plasma clearance (CL) decreased significantly at days 1 and 3 after administration of CCl 4 ( P<0.05). We concluded that the CL change at day 1 corresponds to the acute action of CCl 4 intoxication, and that the change at day 3 is effect of physiologically reduced liver function due to the liver regeneration for tissue repair after the CCl 4 hepatic injury. Sho-saiko-to extract and its components were shown to suppress acute hepatic injury induced by CCl 4, and to bring about an early recovery in liver function.
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