Abstract
Objective To explore the impact of Shenmai injection on the levels of plasma soluble intercellular adhesion molecule-1 ( sICAM-1 ) and ICAM-1 mRNA in the pancreas tissue of rats with severe acute pancreatitis (SAP).Methods One hundred and eight SD male rats were randomly divided into three groups:sham operation group (group A),SAP model group (group B),Shenmai injection group ( group C).The rats in groups B and C were further divided into four subgroups based on the time points of constructing model:4,8,16 and 24 h subgroups (n =12 each).The levels of plasma sICAM-1 and the ICAM-1 mRNA in the pancreas tissue of rats were compared among the three groups.Results The levels of plasma sICAM-1 were significantly higher in group B than in 4,8,16 and 24 h subgroups of group A (128.07±15.86 vs 87.31 ±13.16,142.33±22.61 vs 98.82 ±11.39,187.45±17.39 vs 129.51 ±15.61,and 176.18 ± 19.36 vs 123.57 ± 17.03) ( all P ＜0.05).The levels of plasma sICAM-1 were significantly lower in group C than those in 4,8,16 and 24 h subgroups of group B (92.55 ± 8.09 vs 128.07 ± 15.86,105.28 ± 14.29 vs 142.33 ± 22.61,142.36 ± 18.25 vs 187.45 ± 17.39,131.32 ± 21.83 vs 176.18 ±19.36) ( all P ＜ 0.05 ).The expression of 1CAM-1 mRNA in the pancreatic tissue was significantly higher in group B than that in4,8,16 and 24 h subgroups of group A (0.97 ±0.12 vs 0.52 ±0.11,1.08 ±0.18 vs 0.61±0.13,1.32±0.18 vs0.82±0.14,1.23 ±0.09vs0.74±0.13) (allP＜0.05).The expression of ICAM-1 mRNA in the pancreatic tissue was significantly lower in group C than that in 4,8,16 and 24 h subgroups of group B ( 0.59 ± 0.13 vs 0.97 ± 0.12,0.68 ± 0.09 vs 1.08 ± 0.18,0.96 ±0.20vs1.32±0.18,0.88±0.09vs1.23±0.09) (allP＜0.05).Conclusion Shenmai injection could improve microcirculation and protect rats with SAP through decreasing the levels of plasma sICAM-1and the ICAM-1 mRNA of the pancreas tissue. Key words: Severe acute pancreatitis ; Intercellular adhesion molecule-1 ; Shenmai injection
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