Effects of SGLT2 (Sodium-Dependent Type 2 Glucose Transporters) on Different Systems

Abstract

SGLT2 inhibitors are a class of drugs commonly used in the treatment of type 2 diabetes. Although these drugs are effective in controlling blood sugar, they also have significant systemic side effects that must be considered. The most common side effects of SGLT2 inhibitors include urinary tract infections, euglycemic ketoacidosis, orthostatic hypotension, dehydration, and cardiovascular adverse events. In addition, an increased incidence of bone fractures and decreased bone mineral density has been observed in patients taking these drugs. It is important that physicians consider these side effects when prescribing SGLT2 inhibitors and monitor patients regularly for any complications. Individual benefit-risk assessment is critical before deciding to prescribe these drugs. In summary, although SGLT2 inhibitors are an effective treatment option for type 2 diabetes, their use should be carefully evaluated and monitored to minimize systemic side effects.