Abstract
The activities of three glucocorticoid-inducible enzymes, tryptophan oxygenase, tyrosine aminotransferase and alanine aminotransferase were significantly increased in the livers of female Sprague-Dawley rats by treatment with 10 ng estradiol benzoate daily for 14 days. Although estrogen-treated, adrenalectomised females did not show the same marked increases in tryptophan oxygenase and tyrosine aminotransferase, nevertheless the levels of these enzymes were higher than those of the adrenalectomised controls, whereas alanine aminotransferase was not affected by estrogens after adrenalectomy. It is suggested that the presence of adrenocorticosteroids is necessary for the full expression of the effect of estrogen upon tryptophan oxygenase, and tyrosine aminotransferase, and for the induction of alanine aminotransferase. Tryptophan oxygenase was reduced by ovariectomy or testosterone propionate injection, as well as by adrenalectomy. Untreated, intact male rats had significantly lower tryptophan oxygenase lev...
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