Abstract
For laparoscopic surgery, it is very difficult to assess the effect of different medicines used in the surgical procedure on the surgical results. In the past, doctors could use sevoflurane to numb and calm patients. For decades, this type of treatment has been fairly reliable and effective, but for laparoscopic surgery, the use of sevoflurane can lead to a wide range of blood glucose changes, so in recent years, sevoflurane compared to propofol in laparoscopic surgery on endogenous and nitrogen oxide metabolism has been studied more and more. In this paper, a variety of research methods were used to study the phenomenon of shock and excessive anesthesia encountered by patients in the treatment process. Through observation and drug experiment of patients in different treatment courses and treatment stages, patients were asked to use sevoflurane and propofol to conduct double-blind experiments on their own drug effects. At the same time, through the long-term observation of patients with different diseases and patients who need laparoscopic surgery, the nitrogen oxide metabolism in patients with sevoflurane compared with propofol endogenous was studied and analyzed. Through three groups of different conditions, the experimental group, the blind test group, and the control group were studied. To conclude, in laparoscopic surgery, the use of sevoflurane compared with propofol can have a good impact on the endogenous drug and nitrogen oxide metabolism. It can achieve a good effect on the anesthesia effect of surgery, the maintenance of patient's physical signs and heart rate, which is very beneficial to the operation. Conclusion. Sevoflurane compared with propofol has a good effect on endogenous nitrogen oxide metabolism in laparoscopic surgery.
Highlights
In today’s medical research, there are a variety of studies on the use of drugs in laparoscopic surgery to produce a good impact on the metabolism of nitric oxide in patients [1]
Due to the complexity of various factors in the operation, including the patient’s psychological state, the patient’s physical quality, and the doctor’s status, in order to enable the doctor to have a stable working environment during the operation, whether the influence of sevoflurane compared with propofol on endogenous nitric oxide metabolism in laparoscopic surgery can achieve stable improvement has become a hot research area
Endotracheal intubation was performed after muscle relaxation. e anesthesia machine was adjusted, the tidal volume of mechanical ventilation was set to 7–9 ml/kg, with respiratory rate of 10–12 times/min, and the end expiratory carbon dioxide partial pressure (PetCO2) was maintained at 35–40 mmHg. e patients were given propofol target-controlled infusion (TCI plasma target concentration 2–4 μg/ml), sevoflurane inhalation 1%–3%, propofol target controlled infusion combined with sevoflurane inhalation, combined with vecuronium and remifentanil (TCI plasma target concentration of 4 ng/ml) to maintain anesthesia
Summary
In today’s medical research, there are a variety of studies on the use of drugs in laparoscopic surgery to produce a good impact on the metabolism of nitric oxide in patients [1]. A large number of foreign scholars have made excellent research on the effect of sevoflurane compared with propofol on endogenous nitric oxide metabolism in laparoscopic surgery. Bagia et al used a large number of experimental research methods in its research, compared different patients in the experimental group and the control group using sevoflurane and propofol, and concluded that the use of this drug in laparoscopic surgery can greatly reduce the side effects of patients and improve the therapeutic effect [2, 3]. Kopman and Naguib used a lot of experimental comparison methods in their research and compared the patient’s physical state and the healing process, and after a long-term study, it was concluded that the patient’s physical signs discomfort was reduced a lot after using sevoflurane and propofol and achieved good therapeutic effect [7]. P < 0.05 means the difference is statistically significant [16, 17]
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