Effects of serum uric acid levels on coronary collateral circulation in patients with non-ST elevation acute coronary syndrome

Abstract

The strong relationship between high level of serum uric acid (UA) and cardiovascular disease has been shown in many studies. In this study, we investigated whether serum UA levels affect coronary collateral circulation (CCC) in patients with non-ST elevation acute coronary syndrome. The study population included 175 patients with non-ST elevation acute coronary syndrome. On the first day of admission to the hospital, blood samples were taken and UA levels were analyzed for all patients. Coronary angiography was performed on patients within 24-72 h. Rentrop collateral classification was performed. Patients were divided into two groups on the basis of UA levels: group I consisted of 102 patients (90 male, 12 female) with normal UA levels and group II consisted of 73 patients (59 male, 14 female) with elevated UA levels. Group 2 had a significantly higher rate of poorly developed CCC and a lower rate of well-developed CCC compared with group 1 (P=0.003 and 0.001, respectively). Patients with poor CCC had significantly higher serum UA levels compared with patients with well-developed CCC (6.5±1.1 vs. 5.5±1.7 mg/dl, P=0.028). Linear regression analyses showed that poor CCC development was significantly associated with serum UA levels (coefficient=0.22, P=0.005). Serum UA level on admission is associated with poor CCC development and may be a useful biomarker for stratification of risk in patients with non-ST elevation acute coronary syndrome.