Abstract
Objective To analyse the clinical value of HBV large surface protein(LHBs)in the therapeutic observation of adefovir dipivoxil on chronic hepatitis B.Methods The levels of serum LHBs、HBV DNA、 HBeAg of 30 chronic hepatitis B cases with anti-viral of adefovir dipivoxil were detected at the time of 0,6,12,18,24 months.Results There was no statistical difference between the positive rate of LHBs(90.00%) and HBV DNA(100%) (χ~2=3.16,P > 0.05).LHBs levels were correlated with the logarithm of HBV DNA copies (r=0.912).There was no statistical difference between the positive rate of HBeAg(80.00%)and LHBs(χ~2=1.18,P > 0.05).Conclusions The serum LHBs has a good consistency with HBV DNA.It can be used as a new indicator of viral replication.The long LHBs positive duration indicates the high risk of invalid anti-viral treatment. Key words: Hepatitis B; chronic; Anti-viral treatment; Large surface protein; Adefovir dipivoxil
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