Abstract
The aim of this study was to investigate the effects of Sertraline on gonad-pituitary cycle (Testosterone, FSH and LH) and reproductive cells in adult male Balb/C mice. Adult male Balb/C mice were divided into the following 5 groups: control group with no treatment, sham group which received solvent, and the experimental groups which received one dose of Sertraline (0.0178 mg/kg) in the first group, two doses of Sertraline (0.0356 mg/kg) in the second group, and three doses of Sertraline (0.0534 mg/kg) in the third group. Mice were anaesthetized after 7 weeks. Serum samples were collected and Testosterone, FSH and LH levels of serum were assayed. Vase deferans were analyzed for motility, number and viability of sperms. The results of this study showed that the viability, count and motility of sperms were decreased. Testosterone level of blood was also decreased while FSH was increased. There was no significant change in LH level. It is suggested that Sertraline at higher dose decreases sperm production and has the potential to affect adversely fertility in male mice.
Highlights
Sertraline, a member of the class of the selective serotonin reuptake inhibitors (SSRIs), is a compound primarilyHow to cite this paper: Jahromy, M.H. and Moghadam, A.A. (2014) Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, follicle stimulation hormone (FSH) and LH in Adult Male Mice
We investigated the effects of sertraline, on motility, number and viability of sperm and its relation to Testosterone, FSH and LH levels of blood in adult male Balb/C mice
The results indicate a significant decrease in motility, number and viability of sperm after seven week sertraline administration, in a dose-dependent manner
Summary
Sertraline, a member of the class of the selective serotonin reuptake inhibitors (SSRIs), is a compound primarilyHow to cite this paper: Jahromy, M.H. and Moghadam, A.A. (2014) Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, FSH and LH in Adult Male Mice. Sertraline, a member of the class of the selective serotonin reuptake inhibitors (SSRIs), is a compound primarily. How to cite this paper: Jahromy, M.H. and Moghadam, A.A. (2014) Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, FSH and LH in Adult Male Mice. A. Moghadam used as an antidepressant drug, but it is applied in the correction of other psychic deviations like obsessive compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), posttraumatic stress disorders (PTSD) [1]. Treatment strategy is strongly influenced by factors such as type of depression, patients’ previous response to treatment, drug-related mood instability, drug interactions, safety and tolerability profile, compliance, latency in overdose, combined psychiatric disorders [2]
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