Abstract
Muricidal behavior induced in rats by social isolation or by olfactory bulb ablation was blocked following IP administration of serotonin (5–HT) agonist 8-OH-DPAT and 5-MeODM and by 5-HT uptake inhibitors, fluoxetine and indalpine. Among uptake inhibitors, although fluoxetine has a higher IC50 and a higher Ki, it is apparently more efficient than indalpine. The 5-HT agonist, 8-OH-DPAT, acting at a putative 5-HT1A receptor, appears more efficient on muricidal inhibition than 5-MeODM, at a much lower dosage. It is highly probable that 5-HT1A receptor rather than 5-HT1B is involved in the antimuricidal effect of serotonin-mimetic drugs. Since 5-HT mimetic drugs blocked mouse-killing behavior of bulbectomized rats, we suggest that in the sequence of events in muricidal inhibition 5-HT circuits participate after gabaergic modulation from olfactory bulbs.
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