Abstract
Rats with chronically implanted electrodes were induced by hypothalamic stimulation to drink water. A second electrode was then implanted in the septum of each rat under electrophysiological control. The main components of the evoked potentials (EP) recorded at the hypothalamic “drinking site” to septal stimulation had latencies of 10–14 and 18–23 msec. In behavioral tests a pulse of stimulation to the septum prior to each pulse of stimulation to the hypothalamus facilitated or suppressed water intake. When septal stimulation facilitated drinking the septal electrodes were in the region of the dorsal fornix and the 10–14-msec component of the EP was prominent, whereas with suppression of elicited drinking the electrodes were at more ventral sites in the vicinity of the bed nucleus of the stria terminalis and the 18–23-msec component was prominent in the EP. We conclude that septal stimulation both facilitates and inhibits drinking elicited by hypothalamic stimulation, and it appears that the effects are mediated by different pathways, facilitation of induced drinking by means of the fornix and suppression of drinking by the stria terminalis.
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