Abstract
The effects of selenite on the renal tubular lesion caused by mercuric chloride were studied by electron microscopy using male rats injected with HgCl 2 and/or Na 2SeO 3. The protective effect of selenite on mercury-induced renal injuries was confirmed both in proximal tubular cells and in glomerulus. Mercury specifically deposited in lysosomes in proximal tubular cells of rats which received either mercury alone or mercury plus selenite, although the density of fine gold grains, which revealed the mercury deposits, appeared to be higher in the rats treated with mercury alone than in those administered mercury and selenite. These observations by electron microscopic histochemistry were consistent with the analytical data for mercury in the kidneys. The results suggest that the reduction of renal mercury toxicity by selenite should be ascribed not to the change in subcellular mercury localization but to the decrease in the level of mercury in kidneys.
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