Abstract
1. 1. The effects of selective dopamine receptor compounds on the spontaneous activity of single neostriatal neurons were examined extracellularly. 2. 2. Intravenous administration of quinpirole, the D 2 agonist, elicited a dose-dependent depression in discharge rate. 3. 3. Quinpirole-evoked depression was reversed by the D 2 antagonist eticlopride, but not the D 1 antagonist SCH 23390. 4. 4. The partial D 1 agonist, SKF 38393 induced depression and excitation in equal proportion. 5. 5. A dose of 0.25 mg/kg SCH 23390 blocked SKF 38393-induced depression but not excitation. 6. 6. SKF 38393-induced excitation was antagonized by eticlopride and in some cases by a higher dose of SCH 23390.
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